Italian organic Lycopene produced for dietary supplements industry, pharmaceutical business and pharmacy distribution, a perfect antioxidant for health protection. Italian organic antioxidant coming from tomatoes to protect human.

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Organic Lycopene Italian patented product used to produce dietary health food supplements to the industry. Powerful Organic Dietary Supplements according to the diet health international standards, using our made in Italy organic lycopene, the perfect organic antioxidant for Europe, USA, Middle East and Asia.

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ORGANIC LYCOPENE PRODUCED IN ITALY BY PIERRE SRL Organic lycopene, the perfect and most powerful natural antioxidant extracted in supercritical conditions of CO2, is a unique innovative new product according to the production system and new technology used, our organic lycopene has a strong antioxidant power, to contrast the destructive action of free radicals in the human body, preventing human diseases. Our made in Italy Organic lycopene has the following main characteristics:

1- Organic Lycopene, is 100% natural and organic according to the certification of ICEA
2- Organic Lycopene doesn't contain any toxic substance
3- Organic Lycopene improved natural bioavailability
4- Organic Lycopene improved antioxidant and anticancer activity

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1. ORGANIC LYCOPENE IS 100% NATURAL AND ORGANIC ICEA CERTIFIED

ORGANIC LYCOPENE IS FULL NATURAL - CHEMICAL SOLVENTS FREE The organic lycopene, produced by Pierre srl in Italy, is extracted by supercritical carbon dioxide (SC-CO2) from red-ripe tomato matrices (not skins or other derived wastes). The extract is composed by a mixture of natural compounds, including, in addition to lycopene, other carotenoids ( b -carotene, lutein, zeaxanthin), polyunsaturated fatty acids (omega-3 and omega-6), phytosterols and traces of vitamins.
Organic lycopene is obtained by extraction with supercritical carbon dioxide (SC-CO2) from organic certified red-ripe tomatoes. This process does not involve the use of chemical solvents, so the finished product is solvent-free, 100% natural and organic certified ICEA.

2. OUR ORGANIC LYCOPENE DOES NOT CONTAIN ANY TOXIC SUBSTANCE

ORGANIC LYCOPENE TOXICITY FREE Our Organic Lycopene doesn't contain any toxic substance before, during and after manufacturing process, our organic lycopene is obtained from organic red-ripe tomatoes certified ICEA. Tomatoes are pesticides-free, dioxins-free, heavy metals-free, OGM-free.
Organic lycopene is obtained at moderate temperature (70°C) with a process based on an exclusively physic principle (extraction with supercritical carbon dioxide)
Because this procedure does not involve the use of chemical solvents, the finished product is:
     - solvent-free
     - toxic reaction by-products-free
     - impurity-free
The organic lycopene, made in Italy by Pierre srl, is the unique lycopene 100% natural without any form of toxicity.

3. ORGANIC LYCOPENE IMPROVED NATURAL BIOAVAILABILITY FOR NUTRITIONAL SUPPLEMENT

ORGANIC LYCOPENE AND BIOAVAILABILITY the organic lycopene bioavailability value is usually different from lycopene content. Bioavailability is an important parameter for a nutritional supplement, as it is an evaluation tool of its efficacy and action. Bioavailability is used to describe the quantity of lycopene (or any drug) that reaches the systemic circulation and is available at the site of action. The exceeding molecules are removed from the body.
LYCOPERE BIOAVAILABILITY DEPENDS OF DIFFERENT FACTORS:
     - Lycopene molecular structure, such as physical state, crystal dimensions, isomeric configurations
     - Physical and chemical properties of the lycopene mixture, such as lipid content, β-carotene content, uniformity of the extract, lycopene dosage

4. ORGANIC LYCOPENE IMPROVED ANTIOXIDANT AND ANTICANCER ACTIVITY

CANCER AND FREE RADICALS Many types of cancers are probably the result of interactions between free radicals and DNA, resulting in mutations that can adversely affect the cell cycle and potentially lead to malignancy. Free radicals may also be involved in Parkinson's and Alzheimer's diseases, arthritis, diabete mellitus, dermatitis and other degenerative diseases.

OXIDATION OF THE SKIN DUE TO FREE RADICALS Some of the symptoms of aging such as atherosclerosis are also attributed to the oxidation of many of the chemicals constituting the body induced by free radicals.

FREE RADICALS ARE PART OF OUR LIFE Since free radicals are required for life, the body has a number of mechanisms to reduce their negative action and to repair damage which does occur such as the enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. These endogenous systems need to be supported by the introduction of exogenous antioxidants with the diet which can play a key role in strengthening these defence mechanisms.
MAIN ANTIOXIDANTS The main antioxidants introduced with the diet are: carotenoids (lycopene , β-carotene, lutein, etc.), vitamins (A, C, E) and polyphenols (tannins, flavonoids, anthocyanins, etc.). An antioxidant acts in synergy with others, in a sort of regenerative chain or protection mechanism. Moreover, each antioxidant has a specific action on one or two free radical species, so it is important a complete and balanced diet in order to introduce a large range of antioxidants

LYCOPENE MOLECULAR STRUCTURE - PHYSICAL STATE - LYCOPENE BIOAVAILABILITY IS HIGHLY INFLUENCED BY THE CRYSTALLINE STATE

ORGANIC LYCOPENE IS PRESENT IN EXTRACT PROCESS AS VISCOSE SOLUTION in lipids which are co-extracted with it.
The lycopene absorption and passage into the systemic circulation depends on crystal stability, organic lycopene being already in solution is promptly absorbed and available.
Lycopene bioavailability depends on the dimension of crystals. Recent studies demonstrated that smaller crystals are more easily dissolved in the human body and hence absorbed more rapidly than larger ones (500 nm crystals are 30% more absorbed than 5 mm ones).
ORGANIC LYCOPENE REPRESENTS THE BEST FORM FOR ITS ASSIMILATION because is fundamentally not present in a crystalline state.
Synthetic lycopene has a purity of 90-95%, it is in the form of large and regular crystals obtained after crystallization from a solution in chemical solvents and with low impurities content.
Natural lycopene has a purity of approximately 50-60%, it is in the form of small and not very regular crystals obtained after crystallization from a solution in chemical solvents and with higher impurities content.
LYCOPENE MOLECULAR STRUCTURE: ISOMETRIC CONFIGURATION
In nature, lycopene trans-form is more abundant (>90%) than cis-form, but in human tissues this ratio is the opposite (cis-isomer is > 60%). The cis-form is, in fact, more bioavailable due to a reduced ability to form large crystals with respect to the trans-form. The isomerization from trans-cis could take place during the extraction process or during digestive processes. The two isomeric forms have the same biological activity, but cis-form is more absorbed in human tissues than the trans -one.
A higher cis/trans ratio is strictly connected to a higher bioavailability.
Organic lycopene has a cis/trans ratio 10-20-fold higher than the ones of synthetic and natural lycopene.
PHYSICAL AND CHEMICAL PROPERTIES OF THE LYCOPENE MIXTURE: LIPID CONTENT
Carotenoids are absorbed by the human digestive system with the same emulsification mechanism that allows lipid assimilation. Their absorption depends also on their prompt release from food. The presence of oils or fats accelerates this process promoting the solubilisation of the carotenoid crystals enclosed in foods. Since lipids improves carotenoid absorption at the intestinal level, lycopene containing nutritional supplements include high percentages of vegetable oils. Moreover the absence

ORGANIC LYCOPENE USED AS DIETARY SUPPLEMENT organic lycopene could be used itself as nutritional supplement because it does not need any form of dilution or solubilisation with external oils. The extraction process by supercritical carbon dioxide (SC-CO2) allows to obtain an extract, in which lycopene is uniformly solubilised in the co-extracted vegetable oil. This procedure avoids also the formation of large and stable lycopene crystals with great advantage for lycopene bioavailability.

SYNTHETIC AND NATURAL LYCOPENE can be used in nutritional supplements only diluted with vegetable oils, as high concentration and purity are strictly connected to very low chemical stability and bioavailability. Lycopene is diluted and stabilized by adding vegetable oils, preservatives and other additives. The final concentration of lycopene in nutritional supplements could be in a very large range, from 0,1% up to 10%.

USA FOOD AND DRUGS ADMINISTRATION COMPARISON BETWEEN SYNTETIC, NATURAL AND ORGANIC LYCOPENE:

AT PIERRE WE PRODUCE, IN ITALY, DIETARY SUPPLEMENTS USING OUR OWN ORGANIC LYCOPENE

PHYSICAL AND CHEMICAL PROPERTIES OF LYCOPENE MIXTURE: β-CAROTENE CONTENT

β-CAROTENE CONTENT IN LYCOPENE The Organic lycopene, produced in Italy at supercritical conditions of CO2 by Pierre srl, contains also several carotenoids extracted from tomatoes, such as b-carotene, lutein, zeaxanthin, astaxanthin, phytofluene, etc. Recent studies have demonstrated that lycopene bioavailability is enhanced by the presence of b-carotene.

PHYSICAL AND CHEMICAL PROPERTIES OF LYCOPENE MIXTURE: CONCENTRATION UNIFORMITY OF THE EXTRACT

UNIFORM CONCENTRATION OF LYCOPENE EXTRACTED The organic lycopene extracted, at supercritical conditions of CO2 by Pierre srl, is characterised by an elevated concentration uniformity of lycopene. The absence of lycopene homogeneity or the presence of large and stable crystals could reduce lycopene absorption and consequently the efficacy of the product.

PHYSICAL AND CHEMICAL PROPERTIES OF LYCOPENE MIXTURE: LICOPENE DOSAGE

LYCOPENE DOSAGE AND BIOAVAILABILITY Lycopene bioavailability is not directly proportional to its content in the nutritional supplement. In fact, recent studies demonstrated that lycopene plays its antioxidant role at low concentrations but rapidly lose its capacity at higher doses.
Lycopene suggested dosage is different in several  countries, but average daily dose is 2.5 mg/die, even if recent studies suggest 7.0 mg/die.
Organic lycopene has a dosage of 4.5 mg/capsule.

ORGANIC LYCOPENE: HIGHER ANTIOXIDANT AND ANTITUMORAL ACTIVITY

ORGANIC LYCOPENE EXTRACTION PROCESS The extraction process, by supercritical carbon dioxide (SC-CO2) or by chemical solvents, is not selective, as it gives:  Lycopene and other compounds

ORGANIC LYCOPENE has a high antioxidant activity. It is a mixture of lycopene and other compounds that work in synergy to give a stronger and more effective antioxidant action.

OTHER COMPOUNDS The “other compounds” are very important for health and include: vitamins (E, K), carotenoids (b-carotene, lutein, zeaxanthin, astaxanthin, etc.), polyphenols, essential amino acids (alanine, leucine, tryptophan), polyunsaturated fatty acids.
Natural lycopene is obtained by a process that leads up to high percentages of impurities and extraction chemical solvents. This product needs further purification steps, in order to reduce the toxicity of the final product, but the purification involve also the loss of other important antioxidants, present in the raw materials.

ORGANIC LYCOPENE AND ANTICANCER ACTIVITIES Recent studies demonstrate that, on equal concentrations, a solution of organic lycopene exhibits an antioxidant and anticancer activity at least 100-fold higher than that of a solution of pure lycopene (synthetic or natural). This is confirmed by US FDA studies that underlined that, although a regular consumption of fresh tomatoes (or tomato derivatives) may reduce the incidence of cancers and neurodegenerative diseases, the same preventive effects were not evidenced by supplying dietary supplements containing pure lycopene. This suggests that the optimal biological activity of lycopene is reached only in the presence of other natural molecules contained in  the tomatoes which may act synergistically

Certificato ICEA n. IT BIO ICA PL0279 del "Licopene da agricoltura biologica"

Web site of the "Ministero della Ricerca Italiana": www.ricercaitaliana.it → innovazione ed imprese → alcuni esempi → produzione biologica di licopene naturale → Licopene biologico → Pierre

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Patent WO/2008/015490 Title "Food supplement based on Biological Lycopene and process to obtain Biological Licopene"

Boileau AC, Merchen NR, Wasson K, Atkinson CA,.. -University of Illinois, Urbana-Champaign- USA. Cis-lycopene is more bioavailable than Trans-lycopene in vitro and in vivo in lymph-cannulated ferrets J. Nutr ; 1999, Jun.12

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Dr.A.Venket Rao. Tomatoes , Lycopene & Human Health - Preventing Chronic Diseases . Edited by Caledonian Science Press 2006

Ahuja KD, Pittaway JK, Ball MJ. School of Human Life Sciences, University of Tasmania, Launceston, Australia. Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation . Nutrition. 2006 Jan 12

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Michael McClain R, Bausch J. - McClain Associates, Randolph, NJ, USA - Summary of safety studies conducted with synthetic lycopene . Regul Toxicol Pharmacol. 2003 Apr

Jhonson FJ, Qin J, Krinsky Ni, Russel RM - Ingestion by men of a combined dose of β-carotene and lycopene does not affect the absorption of β-carotene but improves that of lycopene . J Nutr.1997

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Agarwal S, Rao AV - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ont. Tomato lycopene and its role in human health and chronic diseases . CMAJ 2000 Sep 19

Lowe GM, Booth LA, Young AJ ,Bilton RF, School of Biomolecular Sciences, Liverpool.Lycopene and β-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidally lose his capacity at higher doses .- Free Radic. Re. 1999 Beb 30(2) 141-51

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Fuhrman B, Volkova N. Rosenblat M, Aviram M. - Institute for Research in the Medical Sciences, Haifa, Israel. Lycopene synergistically inhibits LDL oxidation in combination with Vitamin E, glabridin, rosmarinic acid , carnosic acid , or garlic -Antioxid Redox Signal. 2000 Fall

Leticia G. Rao, et .., University of Toronto. Endocrinology Round. Will tomatoes prevent osteoporosis? February 2005 Volume 5, Issue 2.

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Laurie Budgar "FDA approves Lycopene Claim". Functional Foods & Nutraceuticals , Jan 2006

Zhou J.-R., Gugger , E.T. & Erdman,J.W (1996). The crystalline form of carotenes and the food matrix in carrot root decrease the relative bioavailability of beta end alfa Carotene in the ferret model. J.Am. Coll. Nutr. 15 : 84-91

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Thomas W. ,M.Boileau , Amy C. Boileau and John W.Erdman Jr. Bioavailaibility of all-trans and cis-isomers of lycopene .Experimental Biology and Medicine (2002) 227 :914-919

Myriam Richelle, Karlheinz Bortlik, Stephanie Liardet, Corinne Hager, Pierre Lambelet, Markus Baur, Lee A. Applegate and Elizabeth A. Offord - Department of Nutrition, Nestlè Research Center, Lausanne, Switzerland. A Food-Based Formulation Provides Lycopene with the Same Bioavailability to Humans as That from Tomato Paste. J. Nutr. 132: 404-408, 2002

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Rao, A. V. & Argawal, S. (1998) Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr. Cancer 3: 199-203

ORGANIC DIETARY AND HEALTH SUPPLEMENTS MANUFACTURING COMPANY TO THE HEALTH CARE INDUSTRY

IMPORTANCE OF LYCOPENE
Recent studies and scientific publications have demonstrated that lycopene has a significant antioxidant activity, twice higher than b-carotene and 10 times higher than vitamin E.
Antioxidants act against the damage caused by free radicals , protecting the body and preventing several diseases. Lycopene seems to be important in the prevention of cardiovascular diseases (atherosclerosis, hypertension, infarction, etc.), m any types of cancers (pancreas, digestive system, breast, liver, prostate), neuro degenerative diseases (Alzheimer's, Parkinson's), osteoporosis , diabete mellitus , male infertility , skin diseases (due to UVA-UVB rays), senile macular degeneration. Lycopene is one of the most important antioxidant in human health and wellness.

Since the human body cannot synthesize lycopene , it must be introduced eating fruits and vegetables or dietary supplements.  Most of the commercially available supplements contain lycopene which has been chemically synthesized or extracted from red-ripe tomatoes by the use of chemical solvents. In both cases, the final product contains residuals of solvents, which are toxic for the body

ORGANIC DIETARY AND HEALTH SUPPLEMENTS MANUFACTURING COMPANY TO THE HEALTH CARE INDUSTRY

ORGANIC LYCOPENE - PRODUCED BY PIERRE GROUP PATENT No. WO/2008/015490

LYCOPENE SUPPLEMENTS FOR DISTRIBUTORS AND PRIVATE LABEL As manufacturing industry we offer high quality certified organic dietary supplements, food supplements and health care supplement products for pharmaceutical treatment using our patented organic Lycopene, we are developing new organic dietary supplements to support world distribution market, furthemore we customized our products for Private Label market APPLY NOW

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